Soft Flow Biotechnology

Last Updated on Monday, 12 March 2012 Published Date


Soft Flow Biotechnology, Ltd.


Soft Flow Biotechnology, Ltd. (SFB), a spin-off company has been jointly established by Agricultural Biotechnology Centre (ABC, and Soft Flow Hungary, Ltd. (SFH, to utilize the intellectual property that had accumulated over the years in ABC’s Diagnostic Laboratory, and facilitate technology transfer in food safety testing from research to industry. The company now commercializes immunoassay reagents and kits for the detection of 5 mycotoxins and 5 antibiotic residues in food and feed.

Tests for mycotoxin contamination of food and feed

Mycotoxin contamination of food and feed is an increasing threat due to different reasons. The changing global climate is favorable for fungal growth. Extensive international trading of raw material and food products require high throughput screening (HTS) technology in food safety testing. Enzyme immunoassays (EIA, ELISA, dip stick tests) are fast, sensitive, reliable, low cost analytical methods which proved useful in first line screening on the spot or in local labs. Positive results are then confirmed in central, reference laboratories.

The very essence of all immunoassays is the antibody that specifically binds to the analyte. Hybridoma technique is a biotechnological method for producing high quality, standardized antibodies called monoclonal antibodies (mAbs). SFB possesses several immortalized hybridoma cell lines producing high quality mAbs for five major mycotoxins: Aflatoxin B1, Ochratoxin A, Fumonisin B1, Zearalenone, and T2 toxin. These antibodies have been tested and approved by prestigious research laboratories and now multinational manufacturer companies use them as crucial components in their immunoassay kits.

SFB is committed to supplying major test developers and manufacturers with good quality anti-mycotoxin monoclonal antibodies and other test components. In addition, SFB is also interested in research and development of new analytical methods that make food safety testing faster, easier and more reliable.

Tests for drug residues in food

Antibiotics (gentamicin, sulfonamids, tetracyclines, beta-lactams, chloramphenicol, macrolides) are often used in animal husbandry as feed additives to increase weight gain and also as prophylactic treatment for bacterial infections. Undesired effects to humans of drug residues in food (milk, meat, egg) can range from allergy induction, toxicity or even mutagenicity. Inappropriate administration of antibiotics can lead to positive selection of pathogenic microorganisms in the environment that became resistant to most antibiotics (multi-drug resistance or MDR). These microbes then often cause fatal human infections because all treatments are ineffective against them. The potential danger of antibiotic misuse has officially been recognized by the EU and maximum residue limits (MRL) were determined for antibiotics in different food products.

ELISA and other immunoassay methods are powerful analytical tools for drug residue testing. SFB’s drug-specific hybridoma cell lines produce high quality mAbs for five drugs that are most often used in food production: Gentamicin, Tylosin, Sulfadiazine, Sulfamethazine and Sulfathiazole. SFB offers these high quality mAbs for sale to international research groups, test developers and manufacturers while it develops its own immunoassay methods, as well.


Soft Flow Biotechnology Ltd.

H-2100 Gödöllő, Hungary

Szent-Györgyi Albert u. 4.

tel.: +36 28 526-160

fax:  +36 28 526-191

e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.


Copyright 2011 Soft Flow Biotechnology.
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